Many phenomena of biological interest originate directly from mechanical motions at the molecular level. Celebrated examples include the trans-cis isomerisation of double bonds that trigger the visual signal and the rotary motion of the enzyme F₁-ATPase, one of the cornerstones of energy conversion in the cell. This extraordinary dependence on molecular level motion in key natural processes is inspiring scientists to try and bridge the gap between synthetic chemistry, which by and large relies upon electronic and chemical effects and does not exploit molecular motions, and the macroscopic world, where our everyday machines rely upon the synchronized motions of their components to perform their designated tasks. Accordingly, there is great current interest in trying to make molecular analogues of some of the fundamental components of machinery from the macroscopic world (cogs, wheels, shuttles, pistons etc). The idea is that such structures could form the basis of synthetic devices or materials that, like biological systems, could function through molecular level mechanical motion. Here we propose a Network which aims to go from developing a simple understanding of how molecular level interlocked components move mechanically with respect to each other, right through gaining control over such motions using external stimuli (electric fields, electrons, photons etc), to the preparation of synthetic materials which change their macroscopic properties in response to a specific signal.